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. 2018 Jan 2;27(4):691–705. doi: 10.1093/hmg/ddx435

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© The Author(s) 2018. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 8. — Expression of human UBTF1 E210K in Drosophila. (A) Expression of WT or UBTF1 E210K results in anatomical abnormalities with Eye3.5-GAL4. Control eye3.5-GAL4 alone flies display normal eye development (left), however expression of UBTF1 with Eye3.5-GAL4 results in a dramatic small-eye phenotype with a complete loss of eye development (right). (B) Expression of UBTF1-E210K resulted in lethality at the pupal stage or earlier. Control Eye3.5-GAL4 alone (left) or Eye3.5 > UBTF1 (center) produced well-recognizable structures including a fully-formed head. However, Eye3.5 > UBTF1-E210K pupae displayed a complete failure of head development within the pupal case.