Table 1.
fam57ba and doc2a genetic mutants affect brain and body size phenotypes. doc2a+/− fam57ba+/− has a stronger effect on increasing hyperactivity and seizures compared to wild-type, while fam57ba−/− has a stronger effect on increasing body size, lipid content, and head size compared to wild-type. Single heterozygotes for each gene as well as doc2a homozygotes do not affect any of these phenotypes, although doc2a−/− larvae have decreased head sizes in one dimension, and increased in other dimensions. This indicates a genuine interaction between doc2a and fam57ba to increase hyperactivity and seizures. Two arrows indicate a stronger effect relative to wild-type compared to a single arrow. A dash indicates no significant differences from wild-type.
| doc+/−fam+/− | fam57ba−/− | fam57ba+/− | doc2a+/− | doc2a−/− | |
|---|---|---|---|---|---|
| Hyperactivity | ↑↑ | ↑ | – | – | – |
| Seizures | ↑↑ | ↑ | – | – | – |
| Body size | ↑ | ↑↑ | – | – | – |
| Lipid content | ↑ | ↑↑ | – | – | – |
| Head Size | ↑ | ↑↑ | – | – | – |