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. 2017 Nov 3;27(1):160–177. doi: 10.1093/hmg/ddx397

Figure 9.

Figure 9.

Proposed models of protein-protein interactions in the mitochondrial IM. (A) Kyte and Doolitle hydrophobicity plot of D2 and D10 obtained with the ProtScale server (58). (B) Structure of D2 and D10 modeled with RaptorX structure prediction server (59). The putative transmembrane helices were predicted using the TMPred server (60). The cysteine residues forming the twin CX9C motifs in CHCHD2 and CHCHD10 are indicated. (C) Hypothetical models of the interaction of CHCHD2 and CHCHD10 with the IM. The schematic incorporates a simulation of the interaction between D2 (green) and D10 (blue) obtained with GRAMMX (Vakser.compbio.ku.edu) and the structure of p32 (PDB # 1P32) from Jiang et al. (40).