Figure 1.

Trem2 deficiency does not alter behavioral or cognitive performance. Six-month-old male and female C57BL/6 N wild type (WT) or Trem2^−/− (KO) mice were examined for behavioral alterations in the open field assay for mobility and anxiety (A–D), elevated plus maze for anxiety (E), and the 3 chamber social test of sociability (F). Contextual (G) and cued (H) cognitive memory performance was determined using conditioned fear assays. Males (blue) and females (red) had similar results. Shown are the averages ± S.E.M. for N = 13–19 animals/group/sex (WT female N = 17, WT male N = 13, KO female N = 14, KO male N = 19). There were no significant genotypes or sex by genotype differences noted in any of the assays (Two-way ANOVA, Fisher’s LSD).