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. 2017 Dec 7;27(3):529–545. doi: 10.1093/hmg/ddx422

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© The Author(s) 2017. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Proposed model of DNAAF1 function in an RT2P-like complex and the IFT-B ciliary transport complex: Unfolded dynein arm components (brown) are folded via the action of DNAAF1 within an ODA pre-assembly module consisting of the AAA+ ATPases RUVBL1 and RUVBL2 (tan), RT2P-like complex proteins (grey) such as DNAAF1, DNAAF2/KTU, and other chaperone proteins (blue) such as SUGT1 and HSP90. In addition to dynein arm assembly through an RT2P-like complex, DNAAF1 also associates with the IFT-B complex (pink; represented by IFT88) allowing dynein arm assembly to be coupled to ciliary transport. RUVBL1 may also have a separate, direct gene regulatory role on asymmetrically expressed genes such as Nodal.