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Burden test comparing familial cases to population controls
| Gene | #Cases | #Families | #Controls | P |
|---|---|---|---|---|
| OCA2 | 8 | 5 | 11 | 0.032 |
| TYR | 6 | 3 | 6 | 0.033 |
| RB1 | 3 | 2 | 3 | 0.084 |
| CDKAL1 | 4 | 2 | 5 | 0.091 |
| HERC2 | 14 | 11 | 39 | 0.093 |
| BRCA1 | 6 | 5 | 13 | 0.124 |
| MITF | 3 | 3 | 5 | 0.125 |
| TYRP1 | 5 | 4 | 10 | 0.143 |
| CDKN2A | 2 | 2 | 3 | 0.177 |
| TINF2 | 2 | 1 | 3 | 0.184 |
| BRCA2 | 6 | 5 | 17 | 0.194 |
| BAP1 | 2 | 2 | 3 | 0.196 |
