Figure 1.

Summed PET images (30–90 min) of [¹¹C] MK-8193 in rhesus monkey brain overlaid on MRI under baseline conditions (A) and after administration of THPP-1 (B). The baseline PET study shows high tracer retention (red color) in the striatum. Tracer binding in the striatum is blocked after administration of THPP-1. Scale is in SUV (standardized uptake value).

[Reprinted from Cox CD, Hostetler ED, Flores BA, Evelhoch JL, Fan H, Gantert L, Holahan M, Eng W, Joshi A, McGaughey. 2015. Discovery of [¹¹C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors, Bioorganic Medical Chemistry Letters, with permission from Elsevier.]