Figure 2.

Plasma concentration vs PDE10A enzyme occupancy relationship in a monkey brain and b rat brain for THPP-1 as determined by PET studies with [¹¹C]MK-8193.

[Reprinted from Hostetler ED, Fan H, Joshi AD, Zeng Z, Eng W, Gantert L, Holahan M, Meng X, Miller P, O'Malley S, Purcell M, Riffel K, Salinas C, Williams M, Ma B, Buist N, Smith SM, Coleman PJ, Cox CD, Flores BA, Raheem IT, Cook JJ, Evelhoch JL. 2015. Preclinical characterization of the phosphodiesterase 10A PET tracer [¹¹C]MK-8193, Mol Imaging Biol, with permission of Springer.]