Table 1.
Examples of zebrafish models for human diseases
| Zebrafish models | Human disease | |
|---|---|---|
| Fish | Experimental conditions | |
| A. Zebrafish models based on alteration of disease associated orthologous genes | ||
| dmdta222a/ta222a [ZDB-FISH-150901-14025] | Generic control [ZECO:0000102] | Muscular dystrophy (Li and Arner 2015) [DOID:9884] |
| rpl11hi3820bTg/hi3820bTg [ZDB-FISH-150901-8506] | Standard conditions [ZECO:0000103] | Diamond-Blackfan anemia (Danilova et al. 2014; Y Zhang et al. 2014; Jia et al. 2013) [DOID:1339] |
| AB + MO1-rps19 [ZDB-FISH-150901-25995] | Standard conditions [ZECO:0000103] | |
| WT + CRISPR1-mecp2 [ZDB-FISH-151014-40] | Standard conditions [ZECO:0000103] | Rett syndrome (Gao et al. 2015) [DOID:1206] |
| col6a1ama605003/ama605003 (TU) [ZDB-FISH-151110-7] | Standard conditions [ZECO:0000103] | Bethlem myopathy (Radev et al. 2015) [DOID:0050663] |
| cfap53hu10478/hu10478 [ZDB-FISH-160504-2] | Standard conditions [ZECO:0000103] | Visceral heterotaxy (Noël et al. 2015) [DOID:0050545] |
| slc16a2biu4/biu4 [ZDB-FISH-150901-10550] | Standard conditions [ZECO:0000103] | Allan-Herndon-Dudley syndrome (Zada et al. 2014) [DOID:0050631] |
| B. Zebrafish models based on gene misexpression | ||
| tp53zdf1/zdf1; Tg(mitfa:Hsa.BRAF_V600E)czt13Tg [ZDB-FISH-150901-14943] | Standard conditions [ZECO:0000103] | Melanoma (Yen et al. 2013) [DOID:1909] |
| Tg(mitfa:mitfa), Tg(rag2:Hsa.MYC-ERT2)zdf14Tg; Tg(lck:lck-EGFP)cz2Tg [ZDB-FISH-150901-17819] | Standard conditions [ZECO:0000103] | Acute T cell leukemia (Ridges et al. 2012) [DOID:5603] |
| Tg(spi1b:LOXP-EGFP-LOXP-Hsa.NUP98-Hsa.HOXA9)hsi1Tg; Tg(hsp70l:Cre)zdf13Tg [ZDB-FISH-150901-25078] | Heat shock [ZECO:0000166] | Myeloid leukemia (Forrester et al. 2011) [DOID:8692] |
| Tg(fabp10a:edn1,myl7:EGFP)nn1005Tg [ZDB-FISH-150901-2358] | Standard conditions [ZECO:0000103] | Hepatocellular carcinoma (Lu et al. 2014) [DOID:684] |
| C. Zebrafish models based on exposure to disease causing conditions | ||
| AB [ZDB-GENO-960809-7] | Chemical treatment: ethanol [ZECO:0000111: CHEBI:16236] | Fetal alcohol spectrum disorders (Fernandes et al. 2015) [DOID:0050696] |
| WT [ZDB-GENO-030619-2] | Increased food availability [ZECO:0000247] | Obesity (Montalbano et al. 2015) [DOID:9970] |
| WT [ZDB-GENO-030619-2] | Bacterial treatment: Mycobacterium marinum [ZECO:0000106: NCBITaxon:1781] | Tuberculosis (Sridevi et al. 2014) [DOID:399] |
| mitfaw2/w2; roya9/a9 [ZDB-FISH-150901-6638] | Viral treatment: influenza virus [ZECO:0000110: NCBITaxon:11309] | Influenza (Gabor et al. 2014) [DOID:8469] |
| D. Zebrafish models based on disease phenotype similarities | ||
| TU [ZDB-GENO-990623-3] | Chemical treatment: pentetrazol [ZECO:0000111: CHEBI:34910] | Epilepsy (Siebel et al. 2015) [DOID:1826] |
| WT [ZDB-GENO-030619-2] | Chemical treatment: oxidopamine [ZECO:0000111: CHEBI:78741] | Parkinson’s disease (Panula et al. 2006) [DOID:14330] |
| WT [ZDB-GENO-030619-2] | Chemical treatment: N-methyl-4-phenylpyridinium [ZECO:0000111: CHEBI:641] | |
| Tg(ins:CFP-NTR)s892Tg [ZDB-FISH-150901-27537] | Chemical ablation: insulin secreting cell [ZECO:0000169: ZFA:0009101], chemical treatment: metronidazole [ZECO:0000111: CHEBI:6909] | Type 1 diabetes mellitus (Tsuji et al. 2014) [DOID:9744] |
Zebrafish models are defined as ‘Fish’ (genotype, background, and STR) and ‘Experimental Conditions’. They are associated with a disease term from the Disease Ontology (DO).