Figure 1.

Ultrasound evaluation of polycystic ovary morphology (PCOM); (left panels) and histologic estimation of the numbers of antral follicles (right panels) in adult female rhesus macaques after chronic exposure to exogenous androgen (testosterone, T) from 1 year of age, with a high-fat/-fructose diet (western-style diet, WSD), compared to age-matched colony controls or WSD alone. PCOM was prevalent in both treatment groups by 14 months on WSD, and the ovaries of WSD and T + WSD--treated animals contained greater numbers of small antral follicles, many undergoing atresia at 18 months on WSD. Adapted from (Bishop et al. 2016).