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. Author manuscript; available in PMC: 2018 Apr 5.
Published in final edited form as: J Immunol. 2017 Jan 23;198(5):1815–1822. doi: 10.4049/jimmunol.1601434

Figure 4. Impact of Il4-hemizygosity on systemic versus intestinal allergic immune responses.

Figure 4

OVA/Alum immunised or naïve (unsensitised) C57BL/6J background mice were i.v. challenged with OVA then monitored for (A) rectal temperature, then (B) the maximum temperature change was determined. (C) BALB/c background mice were immunised i.p. with OVA/Alum four times then i.g. OVA challenged and monitored for diarrhoea. After ten i.g. challenges, (D) jejunal mast cell numbers and (E) serum mMCP-1 levels were determined. Data symbols show (A, B, D) mean + SD (C) group incidence or (E) geometric mean + geometric SD. Data shown (A, B) are combined from 2 experiments (n=4-10 mice/group) or (C-E) are from one experiment (n=3-4 mice/group). In (A, B) one IL-4G4/G4 mouse died at T=35. *p≤0.05, **p≤0.01, ***p≤0.001 by One-Way ANOVA with Tukey's post-test. Data in E were log-transformed prior to statistical analysis.