Table 1. Signals associated with levels of quantitative glycemic traits among non-diabetic subjects in CHNS.
Locus | SNP | Chr | Position | EA/NEA | EAF | Imputation r2 | Genotype | Beta | SE | P-value |
---|---|---|---|---|---|---|---|---|---|---|
Fasting Glucose | ||||||||||
SIX3-SIX2 | rs895636 | 2 | 45,188,353 | T/C | 0.40 | GT | 2124/2709/953 | 0.099 | 0.018 | 2.3 x 10−8 |
G6PC2 | rs34177044 | 2 | 169,754,485 | A/G | 0.37 | 0.70 | 2043/2935/808 | 0.145 | 0.021 | 6.9 x 10−12 |
G6PC2 | rs2232326 | 2 | 169,764,491 | T/C | 0.96 | GT | 5281/488/17 | 0.252 | 0.042 | 1.8 x 10−9 |
HbA1c | ||||||||||
FN3KRP | rs9895455 | 17 | 80,683,980 | T/C | 0.49 | 0.97 | 1821/3504/1853 | 0.095 | 0.018 | 1.0 x 10−7 |
Fasting Insulin | ||||||||||
CNTN6 | rs13078376 | 3 | 932,902 | C/T | 0.69 | 0.69 | 2637/2688/484 | 0.124 | 0.024 | 3.2 x 10−7 |
Results are shown if the association signal reached genome-wide significance (P <5x10-8) or is the strongest association if no signals reached genome-wide significance. Trait values were adjusted for age, age2, BMI, PC1, and sex. Chromosome positions are based on hg19. Effect alleles are associated with higher trait values. Beta estimates reflect per allele effects of variants on inverse normal transformed traits. CHNS, China Health and Nutrition Survey; chr, chromosome; EA, effect allele; NEA, noneffect allele; EAF, effect allele frequency; SE, standard error; GT, genotyped