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. 2018 Apr 5;14(4):e1007275. doi: 10.1371/journal.pgen.1007275

Table 1. Signals associated with levels of quantitative glycemic traits among non-diabetic subjects in CHNS.

Locus SNP Chr Position EA/NEA EAF Imputation r2 Genotype Beta SE P-value
Fasting Glucose
SIX3-SIX2 rs895636 2 45,188,353 T/C 0.40 GT 2124/2709/953 0.099 0.018 2.3 x 10−8
G6PC2 rs34177044 2 169,754,485 A/G 0.37 0.70 2043/2935/808 0.145 0.021 6.9 x 10−12
G6PC2 rs2232326 2 169,764,491 T/C 0.96 GT 5281/488/17 0.252 0.042 1.8 x 10−9
HbA1c
FN3KRP rs9895455 17 80,683,980 T/C 0.49 0.97 1821/3504/1853 0.095 0.018 1.0 x 10−7
Fasting Insulin
CNTN6 rs13078376 3 932,902 C/T 0.69 0.69 2637/2688/484 0.124 0.024 3.2 x 10−7

Results are shown if the association signal reached genome-wide significance (P <5x10-8) or is the strongest association if no signals reached genome-wide significance. Trait values were adjusted for age, age2, BMI, PC1, and sex. Chromosome positions are based on hg19. Effect alleles are associated with higher trait values. Beta estimates reflect per allele effects of variants on inverse normal transformed traits. CHNS, China Health and Nutrition Survey; chr, chromosome; EA, effect allele; NEA, noneffect allele; EAF, effect allele frequency; SE, standard error; GT, genotyped