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. 2018 Apr 5;13(4):e0193565. doi: 10.1371/journal.pone.0193565

Fig 1. Landscape of exome mutations and differential gene expression of frequently-mutated DIPG genes and IL-4 pathway targets in DIPG samples.

Fig 1

(A) Mutational landscape of frequently-mutated DIPG genes and IL-family genes. Exome sequencing was performed on 38 DIPG samples to identify somatic mutations and copy number variations. When possible, tumor samples were compared against matched normal samples. (B) Gene expression of frequently-mutated DIPG genes and IL-family genes. The set of genes is identical to those in Fig A. RNA sequencing was performed on 28 DIPG samples: 18 tumor samples with matched normal samples, 10 unmatched tumor samples. Average fold change and tumor vs. normal p-values were calculated across the set of expressed genes. Note that IL-13Rα1 and IL-13Rα2 are significantly overexpressed in tumor compared to normal, but are mutationally silent.