Table 3. Branch-site tests of positive selection.

Brancha	Log-likelihood model A	Log-likelihood null model A1	2Δℓ	P-value	ωsb	Selected codonsc
Wallaby 1	−10,537.29	−10,537.29	5.2×10−4	0.497	1.000
Koala 1	−10,537.29	−10,537.29	0.00	0.500	1.000
Tasmanian devil 1	−10,537.29	−10,537.29	0.00	0.500	1.000
Opossum 1a	−10,537.29	−10,537.29	0.00	0.500	1.000
Opossum 1b	−10,527.28	−10,531.13	7.70	0.003*	11.328	V513W
Wallaby 2	−10,535.71	−10,535.71	0.00	0.500	1.000
Koala 2	−10,526.31	−10,527.99	3.35	0.034*	2.960	T467G, S1342A, G1449N
Tasmanian devil 2	−10,517.81	−10,523.87	12.12	2.5×10−4***	5.101	E906N, S1076N, A1338S
Human	−10,537.12	−10,537.29	0.34	0.279	43.846
A	−10,537.29	−10,537.29	0.00	0.500	1.000
B	−10,537.29	−10,537.29	0.00	0.500	1.000
C	−10,537.13	−10,537.13	0.00	0.500	1.000
D	−10,537.29	−10,537.29	0.00	0.500	1.000
E	−10,537.13	−10,537.13	0.00	0.500	1.000
F	−10,532.75	−10,533.68	1.85	0.087	150.054
G	−10,526.76	−10,529.87	6.22	0.006*	3.717	S1034, L1384E

^aInternal branches are represented with letters as in Fig 3.

^bd_N/d_S for the class of codons under positive selection.

^cFor each mutation, the first letter and the number correspond to the amino acid in human Dnmt1s, and the last letter corresponds to the mutation observed in the sequence(s) of interest. For the mutation S1034, the final amino acid is not provided because it is not the same in all the descendants of branch G.

*, P < 0.05

***, P < 0.001.