Table 3. Univariable and multivariable analysis of risk factors for the development of HCC.
| Parameters | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| p value | OR (95% CI) | p value | OR (95% CI) | |
| Age>50 years | 0.534 | 1.294(0.575–2.910) | ||
| Gender (male/female) | 0.917 | 0.957(0.423–2.167) | ||
| Smoking (yes/no) | 0.652 | 1.201(0.542–2.665) | ||
| Drinking (yes/no) | 0.522 | 0.662(0.188–2.335) | ||
| Ascites (yes/no) | 0.513 | 0.791(0.391–1.597) | ||
| Hypertension (yes/no) | 0.211 | 1.651(0.752–3.623) | ||
| NLR (high/low) | 0.002 | 3.324(1.582–6.986) | 0.004 | 3.304(1.477–7.394) |
| Platelet count (<30×109/L) | 0.315 | 0.697(0.345–1.409) | ||
| ALT (>40U/L) | 0.235 | 1.533(0.757–3.105) | ||
| AST (>40U/L) | 0.016 | 2.483(1.184–5.208) | 0.065 | 2.147(0.954–4.834) |
| INR (>1.2) | 0.051 | 2.965(0.994–8.841) | 0.088 | 2.656(0.866–8.150) |
| AFP | 0.622 | 1.004(0.987–1.022) | ||
| Child-Pugh Score (Child C vs. Child A) | 0.305 | 2.041(0.522–7.983) | ||
| Child-Pugh Score (Child B vs. Child A) | 0.359 | 1.519(0.621–3.710) | ||
| Estimated blood loss ≥470ml | 0.985 | 1.015(0.208–4.965) | ||
| Intraoperative transfusion (yes/no) | 0.917 | 1.040(0.492–2.202) | ||
| Spleen volume ≥1426mm3 | 0.832 | 0.992(0.921–1.069) | ||
| Portal vein thrombosis (yes/no) | 0.743 | 0.849(0.319–2.257) | ||
| Surgical approach (open splenectomy vs. laparoscopy) | 0.169 | 0.353(0.080–1.555) | ||
| Postoperative complications (yes/no) | 0.515 | 1.277(0.611–2.668) | ||
Abbreviations: NLR, neutrophil-to-lymphocyte ratio; ALT, alanine aminotransferase; AST, aspartate transaminase; INR, international normalized ratio; AFP, alpha fetoprotein.