Table 2.
Association of family history of mood disorder and continuous demographic and clinical variables
| Characteristics | Mood disorder |
Unadjusted P-value | Adjusted P-value | |||
|---|---|---|---|---|---|---|
| No n = 1740 (43.5%) |
Yes n = 2265 (56.5%) |
|||||
| Mean | SD | Mean | SD | |||
| Age (years) | 41.9 | 13.4 | 39.4 | 13.1 | <0.0001 | – |
| Education (years) | 13.3 | 3.4 | 13.6 | 3.1 | 0.0053 | 0.2843 |
| General medical conditions | ||||||
| Categories endorsed | 2.9 | 2.2 | 3.0 | 2.3 | 0.3355 | <0.0001 |
| Total score | 4.3 | 3.8 | 4.1 | 3.6 | 0.0555 | 0.0591 |
| Severity index | 1.3 | 0.7 | 1.2 | 0.6 | <0.0001 | 0.2371 |
| Age at onset of 1st MDE | 28.7 | 15.1 | 23.1 | 13.4 | <0.0001 | <0.0001 |
| Number of episodes | 5.7 | 11.3 | 6.0 | 11.3 | <0.0001 | <0.0001 |
| Length of current episodes (months) | 23.8 | 47.5 | 25.1 | 55.1 | 0.6771 | 0.1795 |
| Length of illness (years) | 13.3 | 12.6 | 16.4 | 13.3 | <0.0001 | <0.0001 |
| Severity of depression | ||||||
| HRSD17 (ROA) | 19.9 | 6.6 | 20.0 | 6.5 | 0.3645 | 0.0597 |
| IDSC30 (ROA) | 35.3 | 11.6 | 35.8 | 11.4 | 0.2444 | 0.1066 |
| Quality of life | ||||||
| WSAS | 23.3 | 9.6 | 23.7 | 9.0 | 0.2826 | 0.1305 |
| Q-LES-Q | 42.0 | 15.4 | 41.6 | 15.2 | 0.4339 | 0.1170 |
| SF-12 | ||||||
| Physical | 48.3 | 12.3 | 50.1 | 11.7 | <0.0001 | 0.2715 |
| Mental | 27.4 | 8.9 | 26.2 | 8.5 | <0.0001 | 0.1344 |
0 means health problems had no effect on work. 10 means health problems completely prevented from work. MDE, Major Depressive Episode; HRSD, Hamilton Rating Scale for Depression; ROA, Research Outcomes Assessor; IDSC, Inventory of Depression Symptomatology – Clinician Rated; WSAS, Work and Social Adjustment Scale; Q-LES-Q, Quality of Life Enjoyment and Satisfaction Questionnaire; SF-12, Short-Form Health Survey. Adjusted for race, sex, ethnicity and age.