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Natural substrates of the six SGLTs in the human body.
| Protein (gene) | Natural substrate |
|---|---|
| SGLT1 (SLC5A1) | Glucose, galactose |
| SGLT2 (SLC5A2) | Glucose |
| SGLT3 (SLC5A4) | Glucose sensor |
| SGLT4 (SLC5A9) | Mannose, glucose |
| SGLT5 (SLC5A10) | Fructose, mannose, glucose, galactose |
| SGLT6/SMIT2 (SLC5A11) | Chiro-inositol |
SGLT: sodium-dependent glucose transporter. Source: adapted from Wright et al.17
