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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Eur J Immunol. 2017 Aug 28;47(12):2059–2069. doi: 10.1002/eji.201747091

Figure 2.

Figure 2

IL-1β enhances development of Tc17 response. Mice were immunized with P18-I10 (CD8 epitope) or PCLUS3-18IIIB (CD4 helper epitope + CD8 epitope), 7 days later, spleens were removed and were stimulated in vitro with PCLUS3-18IIIB peptide overnight and expression of IL-17A was measured in both CD4+ and CD8+ T cells (A. B). The percentage of live P18-I10 tetramer-positive specific CD3+CD8+ T cells expressing CCR6 (Panel C) or RORγt (Panel D) was analyzed. Each experiment was performed three times. Mann Whitney test was used to determine significance. * P<0.05, and **P<0.01.