Table 2.
Mean response to items of the quality‐of‐ life enjoyment and satisfaction questionnaire (Q‐LES‐Q) for depressed patients and community norms
| Q‐LES‐Q Itema | Minor depression (N= 93)b | Major depressive disorder (N= 366)c | Community sample (N= 67)d | Probability of differences (based on two‐tailed t‐test) | |||||
|---|---|---|---|---|---|---|---|---|---|
| Mean | (SD) | Mean | (SD) | Mean | (SD) | MinorD vs. MDD t df P | MinorD vs. Norms t df P | MDD vs. Norms t df P | |
| Physical health | 3.8 | (0.8) | 3.2 | (0.9) | 4.3 | (0.7) | 5.87 457 <0.0001 | 4.11 158 <0.0001 | 9.49 431 <0.0001 |
| Mood | 2.9 | (0.8) | 2.4 | (0.8) | 3.9 | (0.9) | 5.38 457 <0.0001 | 7.40 158 <0.0001 | 13.83 431 <0.0001 |
| Work | 3.1e | (0.9) | 2.7 | (1.0) | 3.9 | (0.9) | 3.26 442e 0.001 | 5.34 143e <0.0001 | 9.16 431 <0.0001 |
| Household activities | 3.0 | (0.8) | 2.7 | (1.0) | 3.8 | (0.9) | 2.68 457 0.008 | 5.92 158 <0.0001 | 8.40 431 <0.0001 |
| Social relationships | 3.1 | (0.8) | 2.6 | (1.0) | 4.1 | (0.9) | 4.47 457 <0.0001 | 7.40 158 <0.0001 | 11.46 431 <0.0001 |
| Family relationships | 3.2f | (0.9) | 2.9 | (0.9) | 4.2 | (0.8) | 2.86 456f 0.005 | 7.25 157f <0.0001 | 11.05 431 <0.0001 |
| Leisure | 2.9 | (0.8) | 2.7 | (1.0) | 4.1 | (0.9) | 1.79 457 0.074 | 8.88 158 <0.0001 | 10.69 431 <0.0001 |
| Ability to function in daily life | 3.3 | (0.8) | 2.9 | (0.8) | 4.5 | (0.7) | 4.31 457 <0.0001 | 9.86 158 <0.0001 | 15.33 431 <0.0001 |
| Sexual drive | 2.8 | (1.1) | 2.2 | (1.1) | 3.9 | (1.0) | 4.70 457 <0.0001 | 6.48 158 <0.0001 | 11.79 431 <0.0001 |
| Economic status | 2.9 | (1.2) | 2.4 | (1.1) | 3.4 | (1.0) | 3.84 457 0.0001 | 2.78 158 0.006 | 6.93 431 <0.0001 |
| Living/housing situation | 3.3f | (1.1) | 3.0 | (1.0) | 3.9 | (0.9) | 2.52 456f 0.012 | 3.66 157f 0.0003 | 6.87 431 <0.0001 |
| Ability to get around physically | 4.5 | (0.7) | 4.1 | (0.9) | 4.8 | (0.5) | 3.99 457 <0.0001 | 3.00 158 0.003 | 6.19 431 <0.0001 |
| Vision | 3.8f | (1.0) | 3.9 | (1.0) | 4.7 | (0.6) | 0.86 456f 0.392 | 6.55 157f <0.0001 | 6.34 431 <0.0001 |
| Overall sense of well‐being | 3.0 | (0.7) | 2.6 | (0.9) | 4.3 | (0.7) | 3.99 457 <0.0001 | 11.59 158 <0.0001 | 14.67 431 <0.0001 |
| Overall life satisfaction | 2.9 | (0.8) | 2.5 | (0.8) | 4.2 | (0.8) | 4.31 457 <0.0001 | 10.14 158 <0.0001 | 15.99 431 <0.0001 |
aFor each item, respondents rate their level of satisfaction during the prior week, using the following response scale: 1 = very poor; 2 = poor; 3 = fair; 4 = good; 5 = very good. The first 14 items are summed to compute a total Q‐LES‐Q score.
bScreen Visit data for N= 93 patients meeting all entry criteria for the minor depression treatment trial described in detail in the text.
cData for N= 366 patients with major depressive disorder were drawn from a multicenter treatment trial (32) Subjects were men and women 18 or older without bipolar disorder, schizophrenia or other psychosis, alcohol or substance abuse or dependence, severe personality disorders, significant suicide risk, or clinically significant or unstable medical condition.
dThe community sample (N= 67) consisted of volunteers with no clinically significant current mental or medical illness, who responded to advertisements seeking comparison subjects for studies conducted at the Columbia University School of Medicine (31).
eIn the minor depression treatment trial, 15 patients subscribed to the added response option “Not applicable; not working” and are excluded from the mean response (which is based on N= 78). In other studies, subjects who are not working are asked to rate their satisfaction with this status, and so are included in the mean response.
fOne subject in the minor depression trial failed to answer this item, resulting in N= 92.