Table 5.

Influence of Time Frames and Covariates on MMP-3 collected at the Six-Month Follow-Up Exam and Days Between Injury and Surgery

Covariate	R² (Unstandardized β) Between Covariate and MMP-3	ΔR² (Unstandardized β) Between Injury and Surgery and MMP-3 after accounting for the covariate
Days Between Injury and Six-Month Follow-up	0.036 (−0.003)	0.001 (−0.001)
Days Between ACLR and Six-Month Follow-up	0.017 (−0.002)	0.021 (−0.003)
Body Mass Index	0.077 (0.037)	0.016 (−0.003)
Sex	0.334 (−0.388) ^*	0.016 (−0.003)
Age	0.028 (0.013)	0.034 (−0.005)
History of previous ACLR	0.044 (−0.168)	0.012 (−0.003)
Concomitant Meniscal Injury	0.077 (0.194)	0.011 (−0.002)
Concomitant Chondral Injury	0.014 (0.082)	0.006 (−0.002)
KOOS Symptoms at Initial Presentation	0.108 (−0.007)	0.032 (−0.004)
KOOS Pain at Initial Presentation	0.002 (−0.001)	0.019 (−0.003)
KOOS Daily Living at Initial Presentation	0.020 (−0.002)	0.038 (−0.005)
KOOS Sports at Initial Presentation	0.021 (−0.002)	0.024 (−0.004)
KOOS Quality of Life at Initial Presentation	0.022 (−0.002)	0.037 (−0.005)
Tegner Activity Scale at Six-Month Follow-Up	0.028 (−0.027)	0.009 (−0.002)

ACLR – Anterior Cruciate Ligament Reconstruction, KOOS – Knee Osteoarthritis and Outcome Score, C2C – Type-II Collagen Cleavage Product, CPII – C-Propeptide of Type-II Collagen Procollagen, ARGS – Alanin-Arginine-Glycine-Serine, IL-6 – Interleukin-6, MMP-3 – Matrix Metalloproteinase-3

Significant F Change at p ≤ 0.05