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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Wiley Interdiscip Rev RNA. 2018 Jan 11;9(2):10.1002/wrna.1462. doi: 10.1002/wrna.1462

Figure 2.

Figure 2

Roles of CIRP as a tumor promoter. CIRP moves from the nucleoplasm into Cajal bodies where it stabilizes hTERC and telomerase complex assembly via protein-protein interaction. CIRP also moves from the nucleus to the cytoplasm where it binds and stabilizes cyclin E1 mRNA, and binds hTERT mRNA, increasing both of these proteins. CIRP also downregulates p53 and upregulates EMT markers, cyclin D1, 4E-BP1, S6 and ERK1/2 by unknown mechanisms. The overall result is increased cell proliferation and cell survival. Arrows and boxes in black represent known roles from literature and red dashed arrows and boxes represent possible mechanisms or connections.