| Slows cell growth via prolonging G1 phase |
Possible interaction with G1 regulators |
Mouse Fibroblasts (BALB/3T3 Cells) |
(Nishiyama et al., 1997) |
| Inhibits proliferation through its function as a stress-induced RBP |
Binds and increases translational efficiency of DNA damage response genes ATR, Trx-1, RPA2 via 3′ UTR binding |
Human Rectal carcinoma cells (RKO cells) |
(R. Yang et al., 2006; R. Yang et al., 2010) |
| Inversely correlates with proliferation/reduced in endometrial cancer compared to normal endometrium |
Maintains normal endometrial function, aside from its role as a stress response protein |
Human Normal Endometrium and Endometrial Carcinoma Tissues |
(Hamid et al., 2003) |
| Slows doubling time in ovarian cancer cells/reduced in malignant compared to benign ovarian tumors |
Prevents malignancy in ovarian tumors |
Human Malignant and Benign Ovarian Tumors, Ovarian Cancer Cells |
(Biade et al., 2006) |
| Decreases proliferation during mammary gland development |
Halts proliferation when it is no longer needed during development |
Transgenic mice expressing hCIRP in mammary glands |
(Lujan et al., 2016) |
| Part of transcriptomic signature for parity |
Breast differentiation leads to transcriptomic changes that decrease the lifetime risk for breast cancer in parous women |
Human breast biopsies |
(Suraj Peri et al., 2012) |
