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. Author manuscript; available in PMC: 2018 Sep 21.
Published in final edited form as: Nature. 2018 Mar 21;556(7699):130–134. doi: 10.1038/nature26139

Extended Data Figure 1. Sequence alignment of MmTPC1, HsTPC1, AtTPC1, MmTPC2 and HsTPC2.

Extended Data Figure 1

Secondary structure assignments are based on the structure of PtdIns(3,5)P2-bound MmTPC1. Red dots mark the ligand binding residues; black dots mark the S4 arginine residues and residues at the gating charge transfer center; cyan dots mark the key S6 gating residues; green dots mark the residues predicted to participate in calcium coordination in EF-hand domains of AtTPC1. MmTPC1 and AtTPC1shares about 25% sequence identity.