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. Author manuscript; available in PMC: 2018 Sep 21.
Published in final edited form as: Nature. 2018 Mar 21;556(7699):130–134. doi: 10.1038/nature26139

Figure 1. Overall structure of MmTPC1.

Figure 1

a, 3D reconstruction of PtdIns(3,5)P2-bound (purple density) MmTPC1 dimer with each subunit in individual color. b, Cartoon representation of MmTPC1 in the same orientations as the EM maps in a. N-acetylglucosamine (NAG) molecules and PtdIns(3,5)P2 are shown as sticks. c, Topology and domain arrangement of MmTPC1 subunit. d, Structure of the 6-TM I and the soluble domain with individual element colored as that in c. Inset: zoomed-in view of the cytosolic soluble domain. e, Structure of the 6-TM II.