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. Author manuscript; available in PMC: 2018 Sep 21.
Published in final edited form as: Nature. 2018 Mar 21;556(7699):130–134. doi: 10.1038/nature26139

Figure 5. Gating mechanism of MmTPC1.

Figure 5

a and b, Structural comparison between the apo closed (grey) and PtdIns(3,5)P2-bound open (green) MmTPC1 with zoomed-in views of the IS3-S6 (a) and IIS3-S6 (b) regions. Arrows indicate the S6 movements. Key gating residues are shown as sticks. IS6 contains a 5-residue π-helix (colored in red). c, Working model for voltage-dependent PtdIns(3,5)P2 activation of MmTPC1. Red arrows mark the direction of the driving force.