Table 5.
Post hoc analysis of biomarker concentration outcomes stratified by tertile of percentage change in body mass during 15 weeks
| Outcome | Δ Biomarker Concentration(Log10 LS Mean ± SE) | Ratio of Geometric Means | Model R2 | P |
|---|---|---|---|---|
| Insulin, μU/mL | 0.41 | <0.001 | ||
| Tertile 2 vs 1 | −0.145±0.09 | 0.72 | ||
| Tertile 3 vs 1 | −0.434±0.08 | 0.37 | ||
| Leptin, ng/mL | 0.34 | 0.003 | ||
| Tertile 2 vs 1 | −0.288±0.09 | 0.52 | ||
| Tertile 3 vs 1 | −0.429±0.10 | 0.37 | ||
| Adiponectin, ng/mL | 0.21 | 0.007 | ||
| Tertile 2 vs 1 | −0.068±0.07 | 0.86 | ||
| Tertile 3 vs 1 | 0.149±0.08 | 1.41 | ||
| C-Reactive Protein, ng/L | 0.09 | 0.13 | ||
| Tertile 2 vs 1 | −0.315±0.16 | 0.48 | ||
| Tertile 3 vs 1 | −0.262±0.17 | 0.55 | ||
| Interleukin-6, pg/mL | 0.24 | 0.08 | ||
| Tertile 2 vs 1 | −0.179±0.09 | 0.66 | ||
| Tertile 3 vs 1 | −0.050±0.08 | 0.89 |
Participants were divided into thirds to align with meaningful weight changes: tertile 1, no weight loss or weight gain [median Δ: 0.0%]; tertile 2, intermediate weight loss [median Δ: −1.3%]; and tertile 3, ≥5% weight loss [median Δ: −7.5%]. This analysis was conducted using the per-protocol (completers) analysis set, including n=48 overall with n=16 per tertile.