. Author manuscript; available in PMC: 2019 Apr 1.

Published in final edited form as: J Hand Surg Am. 2018 Feb 24;43(4):360–367. doi: 10.1016/j.jhsa.2018.01.013

Table 2.

Nerve wraps that are commercially available in the United States

Product Name Manufacturer)	Description	Lab evidence	Clinical evidence

Autologous vein wrapping	Intimal surface of vein placed along epineurium and wrapped circumferentially	Nerve repair: Rat sciatic nerve – decreased perineural scar compared to controls¹³	Nerve repair: 1 case series⁸
Autologous vein wrapping		Compressive neuropathy: Rat sciatic nerve – decreased perineural scar, improved electrophysiologic testing, larger axons compared to controls⁴	Compressive neuropathy: 4 case series^{6,7 21 22}

NeuraWrap Integra Life Sciences)	Bovine-derived type 1 collagen	Nerve repair: Rat sciatic nerve – decreased perineural scar, no difference in axon counts compared to controls⁹	Nerve repair: None
NeuraWrap Integra Life Sciences)	Bovine-derived type 1 collagen	Compressive neuropathy: None	Compressive neuropathy: 2 case series^10,11

AxoGuard Nerve Wrap (Axogen)	Porcine small intestine submucosa	Nerve repair: Rat sciatic nerve – more effectively reduced intraneural fibrosis than vein wrapping¹³	Nerve repair: None
AxoGuard Nerve Wrap (Axogen)	Porcine small intestine submucosa	Compressive neuropathy: None	Compressive neuropathy: 1 case series¹⁴

Seprafilm (Genzyme) Non FDA-indicated	Hyaluronic acid-carboxymethylcellulose film	Nerve repair: Rat sciatic nerve – decreased adhesions compared to control group¹⁷	Nerve repair: None
Seprafilm (Genzyme) Non FDA-indicated	Hyaluronic acid-carboxymethylcellulose film	Compressive neuropathy: None	Compressive neuropathy: None

XWrap Dry (Applied Biologics) Non FDA-indicated	Human amniotic membrane	Nerve repair: Rabbit ulnar nerve and rat sciatic nerve repair models: less perineural fibrosis and adhesion compared to controls¹⁸	Nerve repair: None
XWrap Dry (Applied Biologics) Non FDA-indicated	Human amniotic membrane	Compressive neuropathy: None	Compressive neuropathy: 1 case series¹⁹