TABLE 2.

All-cause mortality in individuals with sarcoidosis versus matched general population comparators

	Sarcoidosis		General population		Adjusted mortality rate difference (95% CI)¶	Hazard ratio (95% CI)
	Deaths per person-years	Adjusted mortality rate (95% CI)#	Deaths per person-years	Adjusted mortality rate (95% CI)#		Model 1+	Model 2§
Subjects n	8207		81 119
Overall	528/47 810	11.0 (10.1–12.0)	3204/479 200	6.7 (6.5–6.9)	2.7 (2.3–3.1)	1.74 (1.59–1.91)	1.61 (1.47–1.76)
Age at inclusion years
18–29	2/4049	0.9 (0.6–1.3)	24/40 689	0.5 (0.3–0.8)	-0.1 (-0.8–0.6)	0.84 (0.20–3.56)	0.69 (0.16–2.96)
30–39	25/12 464	1.6 (1.3–1.9)	109/121 763	0.9 (0.8–1.1)	1.1 (0.3–1.9)	2.24 (1.45–3.46)	1.62 (1.02–2.56)
40–49	41/11 080	3.0 (2.5–3.5)	192/110 249	1.8 (1.5–2.0)	1.9 (1.5–2.2)	2.13 (1.52–2.98)	2.03 (1.45–2.85)
50–59	80/9606	8.6 (7.6–9.6)	476/96 636	5.0 (4.6–5.5)	2.8 (2.0–3.6)	1.70 (1.34–2.15)	1.54 (1.21–1.96)
60–69	156/6999	21.0 (18.8–23.1)	838/71 388	12.3 (11.5–13.0)	9.0 (6.8–11.3)	1.92 (1.62–2.28)	1.65 (1.38–1.96)
70–85	224/3614	72.5 (65.8–79.1)	1565/38 476	42.5 (40.3–44.5)	18.0 (11.2–25.4)	1.61 (1.39–1.84)	1.52 (1.32–1.75)
Sex
Female	260/20 973	11.5 (10.5–12.5)	1659/211 050	6.7 (6.4–7.0)	3.2 (2.5–3.9)	1.64 (1.44–1.87)	1.55 (1.36–1.77)
Male	268/26 838	15.2 (13.9–16.6)	1545/268 150	8.9 (8.4–9.3)	2.6 (2.1–3.1)	1.85 (1.64–2.11)	1.68 (1.47–1.91)

^#: per 1000 person-years, estimated using Poisson models mutually adjusted for age and sex; ^¶: estimated using additive Poisson models adjusted for exponential age and sex, region of residence, country of birth, education and comorbidity (Charlson comorbidity index score; continuous); the model did not converge for age groups 18–29 and 30–39 years, hence estimates are unadjusted rate differences; ⁺: estimated using Cox models adjusted for age (continuous), sex and region of residence; ^§: estimated using Cox models further adjusted for country of birth, education and comorbidity (Charlson comorbidity index score; continuous).