Table 1.
Observed association of high-risk human papillomavirus with cervical intraepithelial lesions in HIV-seropositive women.
| Prevalence, N (%) | CIN2+ prevalence (test positive vs. test negative) | Univariate association with CIN2+, OR [95% CI] | Multivariate | |
|---|---|---|---|---|
| hc2 positive | 727 (61%) | 42% vs. 6.2% | 11 [7.4–16.6]⁎ | n/a |
| Xpert HPV positive | 720 (62%) | 39.2% vs. 8.8% | 6.9 [4.7–9.6]⁎ | n/a |
| HPV16 | 158 (13.6%) | 68.3% vs. 22.3% | 7.5 [5.2–10.9]⁎ | 6.8 [4.5–10.1]⁎ |
| HPV18/45 | 218 (18.8%) | 45.1% vs. 24.2% | 2.6 [1.9–3.5]⁎ | 2.5 [1.8–3.4]⁎ |
| HPV31/33/35/52/58 | 434 (37.3%) | 45.5% vs. 17.5% | 3.9 [3.0–5.1]⁎ | 3.5 [2.6–4.6]⁎ |
| HPV51/59 | 147 (12.7%) | 42.1% vs. 26.1% | 2.1 [1.4–2.9]⁎ | 1.3 [0.87–2.0], P=0.19 |
| HPV39/68/56/66 | 270 (23.3%) | 37.2% vs. 25.1% | 1.8 [1.3–2.3]⁎ | 1.2 [0.89–1.7], P=0.20 |
⁎
P<0.0001. CIN: cervical intraepithelial neoplasia; n/a: not applicable; hc2: hybrid capture-2; HPV: human papillomavirus.