Table 2.
Composite-HSIL versus composite-negativea(n=415) |
Composite-AIN2 versus composite-negativeb(n=234) |
Composite-AIN3 versus Composite-negativec(n=364) |
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---|---|---|---|---|---|---|---|---|---|---|
Variable | n (%) | OR (95% CI) | p-Value | n (%) | OR (95% CI) | p-Value | n (%) | OR (95% CI) | p-Value | |
Age | 35–44 years | 74/131 (56.5) | 1.00 | 0.577 | 21/78 (26.9) | 1.00 | 0.113 | 53/110 (48.2) | 1.00 | 0.991 |
45–54 years | 89/161 (55.3) | 0.95 (0.60–1.52) | 18/90 (20.0) | 0.68 (0.33–1.40) | 71/143 (49.7) | 1.06 (0.64–1.75) | ||||
55–64 years | 52/84 (61.6) | 1.25 (0.71–2.20) | 10/42 (23.8) | 0.85 (0.35–2.03) | 42/74 (56.8) | 1.41 (0.78–2.56) | ||||
65+ years | 17/39 (43.6) | 0.60 (0.29–1.23) | 2/24 (8.3) | 0.25 (0.05–1.18) | 15/37 (40.5) | 0.73 (0.34–1.57) | ||||
HIV status | HIV-negative | 128/263 (48.7) | 1.00 | <0.0011 | 30/165 (18.2) | 1.00 | 0.0401 | 98/233 (42.1) | 1.00 | <0.0011 |
HIV-positive | 104/152 (68.4) | 2.29 (1.50–3.47) | 21/69 (30.4) | 1.97 (1.03–3.76) | 83/131 (63.4) | 2.38 (1.53–3.70) | ||||
Smoking status | Never | 120/223 (53.8) | 1.00 | 0.104 | 26/129 (20.2) | 1.00 | 0.586 | 94/197 (47.7) | 1.00 | 0.084 |
Past | 76/138 (55.1) | 1.05 (0.69–1.61) | 18/80 (22.5) | 1.15 (0.58–2.25) | 58/120 (48.3) | 1.03 (0.65–1.61) | ||||
Current ≤10PY | 12/19 (63.2) | 1.47 (0.56–3.88) | 5/12 (41.7) | 2.83 (0.83–9.64) | 7/14 (50.0) | 1.10 (0.37–3.24) | ||||
Current >10PY | 24/35 (68.6) | 1.87 (0.88–4.01) | 2/13 (15.4) | 0.72 (0.15–3.45) | 22/33 (66.7) | 2.19 (1.01–4.76) | ||||
HPV16 status | Negative | 114/273 (41.8) | 1.00 | <0.0011 | 40/199 (20.1) | 1.00 | 0.0931 | 74/233 (31.8) | 1.00 | <0.0011 |
Positive | 114/136 (83.8) | 7.23 (4.31–12.11) | 11/33 (33.3) | 1.99 (0.89–4.43) | 103/125 (82.4) | 10.06 (5.88–17.20) | ||||
Number of HR-HPV types | 0 | 25/134 (18.7) | 1.00 | <0.001 | 9/118 (7.6) | 1.00 | <0.001 | 16/125 (12.8) | 1.00 | <0.001 |
1 | 55/98 (56.1) | 5.58 (3.09–10.06) | 10/53 (18.9) | 2.82 (1.07–7.41) | 45/88 (51.1) | 7.13 (3.65–13.94) | ||||
2 | 66/84 (78.6) | 16.00 (8.11–31.51) | 17/35 (48.6) | 11.44 (4.43–29.56) | 49/67 (73.1) | 18.55 (8.73–39.38) | ||||
3+ | 82/93 (88.2) | 32.50 (15.16–69.83) | 15/26 (57.7) | 16.52 (5.88–46.41) | 67/78 (85.9) | 41.49 (18.17–94.76) | ||||
Lifetime receptive partners with a condom | 0–1 | 5/24 (20.8) | 1.00 | <0.001 | 0/19 | <0.001 | 5/24 (20.8) | 1.00 | <0.001 | |
2–5 | 19/52 (36.5) | 2.19 (0.69–6.96) | 2/35 (5.7) | N/A | 17/50 (34.0) | 1.96 (0.61–6.27) | ||||
6–10 | 25/42 (59.5) | 5.59 (1.58–19.75) | 4/21 (19.1) | N/A | 21/38 (55.3) | 4.69 (1.33–16.53) | ||||
>10 | 176/286 (61.5) | 6.08 (2.15–17.22) | 45/155 (29.0) | N/A | 131/241 (54.4) | 4.53 (1.60–12.79) | ||||
Lifetime receptive partners without a condom | 0–1 | 18/63 (28.6) | 1.00 | <0.001 | 4/49 (8.2) | 1.00 | 0.018 | 14/59 (23.7) | 1.00 | <0.001 |
2–5 | 52/105 (49.5) | 2.45 (1.24–4.86) | 18/71 (25.4) | 3.82 (1.17–12.53) | 34/87 (39.1) | 2.06 (0.97–4.37 | ||||
6–10 | 56/85 (65.9) | 4.83 (2.25–10.36) | 5/34 (14.7) | 1.94 (0.47–7.95) | 51/80 (63.8) | 5.65 (2.48–12.88) | ||||
>10 | 106/162 (65.4) | 4.73 (2.41–9.30) | 24/80 (30.0) | 4.82 (1.49–15.57) | 82/138 (59.4) | 4.71 (2.27–9.78) | ||||
Previous six months, receptive partners with a condom | None | 91/180 (50.6) | 1.00 | 0.022 | 13/102 (12.8) | 1.00 | <0.001 | 78/167 (46.7) | 1.00 | 0.194 |
One | 40/70 (57.1) | 1.30 (0.75–2.28) | 8/38 (21.1) | 1.83 (0.68–4.87) | 32/62 (51.6) | 1.22 (0.68–2.19) | ||||
2–5 | 53/94 (56.4) | 1.26 (0.76–2.09) | 15/56 (26.8) | 2.50 (1.08–5.83) | 38/79 (48.1) | 1.06 (0.62–1.81) | ||||
>5 | 48/71 (67.6) | 2.04 (1.14–3.66) | 15/38 (39.5) | 4.46 (1.78–11.17) | 33/56 (58.9) | 1.64 (0.88–3.04) | ||||
Previous six months, receptive partners without a condom | None | 103/197 (52.3) | 1.00 | 0.004 | 16/110 (14.6) | 1.00 | <0.001 | 87/181 (48.1) | 1.00 | 0.054 |
One | 62/121 (51.2) | 0.96 (0.61–1.51) | 14/73 (19.2) | 1.39 (0.63–3.08) | 48/107 (44.9) | 0.88 (0.54–1.42) | ||||
2–5 | 39/62 (62.9) | 1.55 (0.86–2.79) | 12/35 (34.3) | 3.07 (1.25–7.54) | 27/50 (54.0) | 1.27 (0.68–2.38) | ||||
>5 | 28/35 (80.0) | 3.65 (1.49–8.93) | 9/16 (56.3) | 7.55 (2.27–25.09) | 19/26 (73.1) | 2.93 (1.16–7.42) |
Numbers do not always add up to column totals because of small amounts of missing data.
PY: Pack Years.
1 Score test of homogeneity, else the p-values presented are score test for trend of odds.
a Comparing men with composite negative result (n=183) to men with HSIL detected on by either cytology or histology (n=232).
b Comparing men with composite negative result (n=183) to men with HSIL-AIN2 on cytology and/or AIN2 on histology without a diagnosis of AIN3 on either (n=51).
c Comparing men with composite negative result (n=183) to men with HSIL-AIN3 on cytology or histology (n=181).
Men in the composite-LSIL (n=155) and composite-ASC-H (n=55) were excluded from analyses of risk factors.
Row percentages presented.