Table 3.
Multivariate analysis of sexual behaviour risk factors for prevalent composite-HSIL in the Study of the Prevention of Anal Cancer, overall and stratified by composite-AIN2 and composite-AIN3 diagnoses.
|
Composite-HSIL versus composite-negativea(n=415) |
Composite-AIN2 versus composite-negativeb(n=234) |
Composite-AIN3 versus Composite-negativec(n=364) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variable | n (%) | Adjusted OR (95% CI) | p-Value | n (%) | Adjusted OR (95% CI) | p-Value | n (%) | Adjusted OR (95% CI) | p-Value | |
| HIV status | HIV-negative | 128/263 (48.7) | 1.00 | 0.0351 | 30/165 (18.2) | 1.00 | 0.4361 | 98/233 (42.1) | 1.00 | 0.0311 |
| HIV-positive | 104/152 (68.4) | 1.69(1.03–2.76) | 21/69 (30.4) | 1.35 (0.64–2.85) | 83/131 (63.4) | 1.74 (1.05–2.87) | ||||
| Lifetime receptive partners with a condom | 0–1 | 5/24 (20.8) | 1.00 | 0.032 | ||||||
| 2–5 | 19/52 (36.5) | 1.79 (0.66–4.87) | ||||||||
| 6–10 | 25/42 (59.5) | 2.24 (0.82–6.11) | ||||||||
| >10 | 176/286 (61.5) | 2.51 (1.03–6.08) | ||||||||
| Lifetime receptive partners without a condom | 0–1 | 18/63 (28.6) | 1.00 | 0.001 | 14/59 (23.7) | 1.00 | <0.001 | |||
| 2–5 | 52/105 (49.5) | 2.24 (1.13–4.42) | 34/87 (39.1) | 2.08 (0.99–4.36) | ||||||
| 6–10 | 56/85 (65.9) | 3.92 (1.90–8.12) | 51/80 (63.8) | 5.07 (2.37–10.85) | ||||||
| >10 | 106/162 (65.4) | 3.26 (1.62–6.56) | 82/138 (59.4) | 3.61 (1.74–7.49) | ||||||
| Previous six months, receptive partners with a condom | None | 13/102 (12.8) | 1.00 | 0.044 | ||||||
| One | 8/38 (21.1) | 1.67 (0.62–4.52) | ||||||||
| 2–5 | 15/56 (26.8) | 2.06 (0.84–5.00) | ||||||||
| >5 | 15/38 (39.5) | 2.66 (0.96–7.39) | ||||||||
| Previous six months, receptive partners without a condom | None | 16/110 (14.6) | 1.00 | 0.045 | ||||||
| One | 14/73 (19.2) | 1.26 (0.56–2.82) | ||||||||
| 2–5 | 12/35 (34.3) | 1.84 (0.66–5.08) | ||||||||
| >5 | 9/16 (56.3) | 4.16 (1.13–15.27) | ||||||||
1 Score test of homogeneity, else the p-values presented are score test for trend of odds.
a Comparing men with composite negative result (n=183) to men with HSIL detected on by either cytology or histology (n=232).
b Comparing men with composite negative result (n=183) to men with HSIL-AIN2 on cytology and/or AIN2 on histology without a diagnosis of AIN3 on either (n=51).
c Comparing men with composite negative result (n=183) to men with HSIL-AIN3 on cytology or histology (n=181).
Men in the composite-LSIL (n=155) and composite-ASC-H (n=55) were excluded from analyses of risk factors.
Adjusted for age, smoking exposure and the variables presented in the table.