Table 1.
Clinicopathologic characteristics of the 247 study participants stratified by HPV DNA and by HPV-driven status.
| Total | HPVDNA_ | HPVDNA+ | HPV-driven | ||
|---|---|---|---|---|---|
| Characteristicsa | N=247 | N=226 | N=21 | N=15/19 tested | |
| Age (Median, y) | 65 | 65 | 68 | 68 | |
| N (%) | N (%) | N (%) | N (%) | ||
| Gender | Male | 188 (76) | 173 (76) | 15 (71) | 9 (60) |
| Female | 59 (24) | 53 (24) | 6 (29) | 6 (40) | |
| Tobaccob | Never | 79 (32) | 69 (31) | 10 (48) | 8 (53) |
| Former | 34 (15) | 30 (13) | 4 (19) | 3 (20) | |
| Current | 124 (50) | 118 (52) | 6 (28) | 3 (20) | |
| Missing | 10 (4) | 9 (4) | 1 (5) | 1 (7) | |
| Alcoholb | Never | 75 (30) | 69 (31) | 6 (28) | 5 (33) |
| Former | 29 (12) | 26 (11) | 3 (14) | 1 (7) | |
| Current | 131 (53) | 120 (53) | 11 (53) | 8 (53) | |
| Missing | 12 (5) | 11 (5) | 1 (5) | 1 (7) | |
| Localization | Oral cavity | 63 (26) | 62 (28) | 1 (5) | 1 (7) |
| Oropharynx | 63 (26) | 46 (20) | 17 (81) | 13 (86) | |
| Larynx | 96 (39) | 95 (42) | 1 (5) | 1 (7) | |
| Hypopharynx | 25 (9) | 23 (10) | 2 (9) | 0 | |
| Tumor size | T1-T2 | 124 (50) | 113 (50) | 11 (52) | 8 (53) |
| T3-T4 | 123 (50) | 113 (50) | 10 (48) | 7 (47) | |
| Lymph nodes | N0 | 128 (52) | 123 (54) | 5 (24) | 4 (27) |
| N+ | 119 (48) | 103 (46) | 16 (76) | 11 (73) | |
| Metastasis | M0 | 244 (99) | 223 (99) | 21 (100) | 15 (100) |
| M+ | 3 (1) | 3 (1) | 0 | 0 | |
a
P-value (by chi-square analyses) referred to the HPV-DNA+ and HPV-DNA- groups was statistically significant (0.0001) only for oropharyngeal localization.
b
For statistical analyses, tobacco and alcohol categories were simplified in never and current (which includes current and former) tobacco/alcohol consumers.