Fig. 7.

CAMERA gene set testing of CD8 T cell immunologic gene sets from MSigDB C7 in grafting comparisons. (A) Photographs of representative grafts from the various donors and recipients prior to sample collection at 14DPG or 28DPG. (B) Top 5 CD8 T cell related immunological gene sets from CAMERA gene set testing. The significance value of the CAMERA gene set test, Log10 transformed false discovery rate (FDR) adjusted p-values, for each gene set are plotted along the viridis colour scale (purple, blue, green to yellow) in each bubble as well as on the x-axis where the direction regulation of the of the gene set (up or down; +1 or −1) is multiplied to the significance value. The size of the bubbles correspond to the proportion of genes that are up-regulated in each gene set calculated by ROAST. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)