Table 5.
Logistic regression modeling in order to identify factors associated with VTE complications in patients with CD
| Univariate logistic regression | Multivariate logistic regression | |||||
|---|---|---|---|---|---|---|
| OR | 95% CI | p value | OR | 95% CI | p value | |
| Sex | ||||||
| Male | 1.80 | 0.87–3.72 | 0.11 | |||
| Age at diagnosis | ||||||
| <40 years old | 0.32 | 1.15–0.70 | 0.004 | |||
| Disease duration | 1.05 | 1.01–1.10 | 0.01 | |||
| Disease location | ||||||
| Colonic | 22.5 | 2.8–180.9 | 0.003 | |||
| Ileocolonic | 17.8 | 2.33–136.5 | 0.005 | |||
| Behavior | ||||||
| Stricturing | 2.3 | 0.55–3.52 | 0.48 | |||
| Fistulizing | 2.3 | 0.91–5.81 | 0.07 | |||
| Perianal | 1.19 | 0.49–2.88 | 0.69 | |||
| Treatment | ||||||
| Immunossupressors | 1.58 | 0.61–4.11 | ||||
| Biologic | 2.65 | 1.14–6.19 | 0.05 | |||
| Corticosteroid | 427 | 51.9–3518.3 | 0.001 | 403 | 42–3870 | < 0.001 |
| BMI | 0.93 | 0.86–1.02 | 0.13 | |||
| Smoking | 7.02 | 3.01–16.4 | 0.001 | 7.4 | 1.73–3.15 | 0.006 |
| IBD family history | 2.97 | 0.92–9.57 | 0.06 | |||
| Oral contraceptive | 1.53 | 0.38–6.2 | 0.54 | |||
| Hemoglobin | 0.48 | 0.38–0.63 | 0.001 | |||
| Platelets | 1.004 | 1.0006–1.007 | 0.02 | |||
| CRP | 1.004 | 0.99–1.01 | 0.16 | |||
| Fibrinogen (>400) | 0.35 | 0.04–2.95 | 0.33 | |||
| FVIII (>150) | 0.85 | 0.18–3.97 | 0.84 | |||
| AT deficiency (<79) | 2.24 | 0.43–11.7 | 0.34 | |||
| C protein deficiency (<64) | * | * | * | |||
| S protein deficiency (<55) | 13.9 | 3.05–63.7 | 0.001 | |||
5-ASA aminosalicilates, BMI body mass index, IBD inflammatory bowel disease, CRP C-reactive protein, AT anti-thrombin, *= not include in the model