Figure 4.

Enoxacin has its effect on transformed mouse embryonic fibroblasts (MEFs) independent of Tarbp2 or Prkra: (A) Immunoblot for TARBP2 and PRKRA shows the expression or absence of these proteins based on their genotype in transformed MEFs. (B) Graphical representation of cell numbers for the indicated genotype after enoxacin treatment from day 0 to day 5. Relative units are obtained after normalizing the cell numbers from enoxacin treatment to the cell numbers with DMSO treatment (* P < 0.05 and ** P < 0.005). (B) Expression fold-change of 10 quantified mature microRNAs (miRNAs) in transformed MEF cell lines with the indicated genotype upon enoxacin treatment (* P < 0.05 and ** P < 0.005).