Table 2. Mortality and life span statistics of genetically altered mouse strains with shortened life span.

Gene or protein	Type	Strain	Gender	n	t50 (yr)	tmax (yr)	Reference
Aag, Atm, Mgmt	WT	C57BL/6	M & F	37	2.03	2.87	Meira et al. (2014)
	Aag –/–		M & F	29	1.80	2.50
	Mgmt –/–		M & F	50	1.92	2.77
	Atm –/–		M & F	19	0.56	1.37
	Aag –/– Mgmt –/–		M & F	31	1.67	2.71
ATR	WT		M & F	20	NR	NR	Murga et al. (2009)
	ATRs/s		M & F	27	0.42	0.65
Brca1	WT	129O1a × C57BL/6J	F	32	2.15	2.56	Jeng et al. (2007)
	+/−		F	26	1.94	2.53
Bub3 + Rae1	WT	129Sv/E × C57BL/6	N/A	70	2.08	NR	Baker et al. (2006)
	+/−, +/−		N/A	100	1.84	NR
Casp2	WT	C57BL/6	N/A	64	2.62	3.51	Zhang et al. (2007)
	−/−		N/A	64	2.62	3.25
Cdc42	WT	C57BL/6+/− 129/Sv	M & F	16	2.28	2.49	Wang et al. (2007)
	−/−		M & F	21	1.09	2.50
Cisd2	WT	C57BL/6 (B6)	M & F	49	2.09	2.53	Chen et al. (2009)
	Cisd2−/−		M & F	16	1.28	2.15
Cisd2	WT	C57BL/6	M	40	2.25	2.90	Wu et al. (2012)
	+/–		M	51	2.05	2.57
	–/–		M	27	1.76	2.32
	WT		F	25	2.27	2.50
	+/–		F	47	1.92	2.50
	–/–		F	49	1.83	2.94
DNA pol β	WT	C57BL/6	M	60	2.54	3.19	Cabelof et al. (2006)
	+/–		M	67	2.54	3.19
Fgf-23	−/−	Sv129J	M & F	15	0.12	0.26	Razzaque et al. (2006)
Fn1	WT	C57BL/6	M	39	2.43	NR	Muro et al. (2003)
	Fn1EDA −/−		M	53	1.93	NR
HtrA2/Omi	mnd2/+;Tg	C57BL/6J	M & F	23	N/A	N/A	Kang et al. (2013)
	mnd2/mnd2;Tg		M & F	21	1.28	1.50
Htr1b	WT		N/A	21	2.58	3.14	Sibille et al. (2007)
	−/−		N/A	24	2.05	2.75
IKK-β	MBH-GFP	C57BL/6	M	23	2.41	2.91	Zhang et al. (2013)
	N/Ikbkbl/l		M	24	2.23	2.56
junD	WT	N/A	M & F	35	1.91	2.41	Laurent et al. (2008)
	JunD−/−	N/A	M & F	35	1.66	2.17
Msh2	WT	129S/SvEvTac	M & F	51	NR	NR	Wei et al. (2003)
	−/−		M & F	32	0.58	0.92
Pasg	−/−	129/SvJ/C57BL/6J	N/A	63	0.01	0.07	Sun et al. (2004)
Pparg	WT		F	25	2.35	2.68	Argmann et al. (2009)
	Pparg2−/−		F	26	2.14	2.62
Sirt7	WT	C57Bl/6 × 129Sv	M	98	NR	NR	Vakhrusheva et al. (2008)
	−/−		M	32	0.74	1.60
Socs2	WT	C57BL/6J × FVB	M & F	123	2.10	3.00	Casellas and Medrano (2008)
	hg/hg		M & F	146	1.33	2.59
Stub1	WT	C57BL/6 × 129SvEv	M:82	82	2.08	NR	Min et al. (2008)
			F:84
	−/−		M:58	128	0.89	NR
			F:45
Trp63	WT	K5CrePR1	NR	74	2.23	3.00	Keyes et al. (2005)
	+/−		NR	104	1.74	2.25
Xrcc5	WT		NR	47	2.04	2.40	Vogel et al. (1999)
	Ku86 −/−		NR	89	0.79	1.75
Xrcc6	WT		M & F	27	2.17	2.80	Li et al. (2007)
	Ku70 −/−		M & F	43	0.69	1.45

t50, median life span; tmax, maximum life span; yr, year; WT, wild-type; M, male; F, female; Tg, transgenic; NR, not reported;