. 2018 Feb 14;208(4):1617–1630. doi: 10.1534/genetics.118.300821

Table 3. Gompertz parameters for genetically altered mouse strains with extended life span from a regression line calculated by ln(R_m(t)) = ln(R₀) + αt (see Methods).

Gene or protein	Type	Strain	α	α SE	ln(R₀)	r²	MRDT (yr)
Adcy5	WT	129/SvJ-C57BL/6	3.87	0.94	−9.61	0.71	0.18
	−/−		5.95	0.34	−17.20	0.97	0.12
Agrt1a	WT	C57BL/6 × 129/SvEv	5.20	1.21	−11.15	0.86	0.13
	−/−		3.95	1.30	−10.81	0.70	0.18
Arf/p53	WT	C57BL/6J	2.88	0.32	−7.59	0.94	0.24
	s-Arf/p53		2.80	0.44	−8.05	0.86	0.25
Atg5	WT	C57BL/6	7.30	5.48	−14.40	0.47	0.10
	Atg5-Tg		8.92	1.31	−21.54	0.82	0.08
BubR1^a	WT	C57BL/6-SV129	1.62	0.16	−5.42	0.92	0.43
	mBubR1-Tg		2.61	0.097	−7.48	0.93	0.27
Cat	WT	4033	2.30	0.18	−6.40	0.81	0.30
	MCAT	C57BL/6J	3.00	0.59	−8.80	0.68	0.23
	WT	4403	2.00	0.21	−5.93	0.62	0.35
	MCAT		2.20	0.20	−7.41	0.78	0.32
Cisd2^a	WT male	C57BL/6	7.67	2.86	−17.79	0.71	0.09
	Cisd2-Tg male		6.96	1.84	−19.39	0.83	0.10
	WT female		6.62	2.27	−14.43	0.90	0.10
	Cisd2-Tg female		2.40	0.59	−7.10	0.74	0.29
Clk-1	WT	129Sv/J	3.09	0.64	−6.05	0.89	0.22
	+/−		2.49	0.92	−5.95	0.64	0.28
Dgat1^a	WT	C57BL/6J	1.92	0.53	−5.12	0.66	0.36
	−/−		3.56	0.20	−9.63	0.99	0.19
Esp8	WT	C57BL/6	1.50	0.22	−3.70	0.73	0.46
	−/−		1.98	0.18	−5.15	0.81	0.35
FGF21^a	WT	C57Bl/6J	1.82	0.35	−5.66	0.82	0.38
	FGF21-Tg		2.04	0.40	−7.89	0.87	0.34
Ghrh^a	WT	C57BL/6 × 129SV	1.31	0.18	−3.55	0.90	0.53
	KO		1.53	0.17	−5.12	0.94	0.45
Gpx4^a	WT	C57BL/6	3.11	1.08	−9.18	0.73	0.22
	+/–		5.43	0.72	−15.77	0.95	0.13
hMTH1^a	WT	C57BL/6	3.50	0.65	−8.78	0.81	0.20
	hMTH1-Tg		2.29	0.47	−6.91	0.72	0.30
Htt	WT	129/Sv-	2.30	1.01	−6.03	0.56	0.30
	ΔQ /ΔQ		1.80	0.51	−5.19	0.81	0.39
Igf1	WT	FVB	1.06	0.26	−3.02	0.74	0.65
	Igf1		1.35	0.25	−4.43	0.77	0.51
IκB-α	MBH-GFP	C57BL/6	4.15	0.74	−10.75	0.65	0.17
	MBH-DN IB-α		4.43	0.76	−12.86	0.62	0.16
Irs1	WT (female)	C57BL/6	2.18	0.26	−5.00	0.80	0.32
	−/− (female)		1.94	0.31	−6.45	0.71	0.36
Irs2^a	WT	C57BL/6J	2.99	0.13	−7.29	0.87	0.23
	Brain-specific +/−		6.37	0.33	−17.73	0.85	0.11
Mif	WT	C57BL/6J × 129/SvJ	2.45	0.40	−6.08	0.84	0.28
	−/−		1.90	0.31	−6.02	0.82	0.37
mTOR^a	WT	129 × C57BL/6	1.47	0.45	−4.46	0.68	0.47
	KO		2.41	0.15	−6.94	0.98	0.29
Myc	WT female	C57BL/6	2.19	0.55	−5.88	0.76	0.32
	+/– female		3.19	1.05	−9.64	0.70	0.22
	WT male		2.53	0.21	−7.06	0.96	0.27
	+/– male		2.55	0.36	−7.75	0.90	0.27
PAPP-A	WT	C57BL6 × 129SV/E	2.33	0.35	−5.28	0.71	0.30
	−/−		2.67	0.32	−7.39	0.80	0.26
Pten	WT	C57BL/6 × CBA	2.33	0.14	−5.83	0.97	0.30
	Pten-Tg		2.52	0.24	−7.07	0.95	0.27
RpS6K1	WT	C57BL/6	1.81	0.069	−4.64	0.93	0.38
	−/−		1.73	0.056	−5.30	0.91	0.40
RIIβ	WT	C57BL/6 (males)	3.00	0.31	−7.68	0.85	0.23
	RIIB −/−		3.55	0.34	−10.09	0.88	0.20
Sirt1^a	WT	C57BL/6	2.45	0.49	−7.20	0.81	0.28
	Brain-specific Tg		3.63	0.63	−10.71	0.83	0.19
Slc13a1^a	WT (male)	C57BL/6J × 129/SV	1.79	0.37	−4.34	0.83	0.39
	Nas1 −/− (male)		1.70	0.47	−5.02	0.72	0.41
	WT (female)		0.87	0.13	−2.95	0.86	0.80
	Nas1 −/− (female)		1.69	0.29	−4.31	0.85	0.41
Surf1^a	WT	BDF1 × cre	2.19	0.39	−4.81	0.86	0.32
	−/−		3.41	0.47	−7.82	0.96	0.20
TgTert^a	Sp53	C57BL/6 × DBA/2	2.74	0.33	−6.51	0.95	0.25
	Sp53^a /TgTert		3.34	0.41	−8.14	0.94	0.21
	Sp53/Sp16/SArf		1.47	0.58	−4.86	0.52	0.47
	Sp53/Sp16/SArf/TgTert		2.08	0.65	−7.24	0.77	0.33

α, age-specific exponential coefficient; ln(R0), nonexponential factor in mortality; MRDT, mortality rate doubling time as in $0.693 / α;$ yr, year; WT, wild-type; Tg, transgenic; KO, knockout.

Indicates genes for which the changes in MRDT were statistically significant (P < 0.05).

Table 3. Gompertz parameters for genetically altered mouse strains with extended life span from a regression line calculated by ln(Rm(t)) = ln(R0) + αt (see Methods).

Table 3. Gompertz parameters for genetically altered mouse strains with extended life span from a regression line calculated by ln(R_m(t)) = ln(R₀) + αt (see Methods).