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. 2018 Apr 5;19:47. doi: 10.1186/s13059-018-1426-0

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© The Author(s). 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Differentiation trajectories of progenitor cells derived from hPSC. a Differentiation trajectories of progenitor cells constructed by Monocle. b Heatmaps show TFs expression dynamics during differentiation. Genes are listed in Additional file 8: Table S7. Genes (row) are clustered and cells (column) are ordered according to the pseudotime development. In each heatmap, TFs are divided into three clusters (I, II, and III). Specific TFs are listed on the right to show their expression dynamics