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. 2018 Apr 5;12:49. doi: 10.1186/s12918-018-0576-8

Fig. 3.

Fig. 3

Layered network of the simplified MAPK network. The layered network defined in Methods consists of green, yellow and red nodes in all 6 layers, where the yellow nodes denote mutated CREB and PPP2CA and 14 red nodes can be candidates for control nodes for the desired value of the phenotype node Proliferation. The other 12 white nodes denote those nodes that are not layered nodes