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. 2017 Dec 23;21(4):382–392. doi: 10.1093/ijnp/pyx118

Figure 1.

Figure 1.

17β-estradiol (E2) treatment increases cocaine conditioned place preference (CPP) in ovariectomized mice. (A) Timeline and design of the CPP experiment (5 mg/kg cocaine). (B) Graph of the time spent on the cocaine-paired side (in seconds) before conditioning (Test 1) and after conditioning (Test 2) in vehicle (VEH; n = 23)- and E2 (n = 21)-treated mice. Significant main effects by 2-way RM ANOVA: **P < .01 and ****P < .0001. #Indicates a significant difference (P < .01) between VEH and E2 on Test 2; significant difference (*P < .05 and ****P < .0001) between Test 1 and Test 2 within each treatment group by posthoc Holm-Sidak’s multiple comparisons test. (C) Preference scores (Test 2 –Test 1, in seconds) of VEH- and E2-treated mice (*P < .05 by Student’s t test). Data are presented as the mean ± SEM.