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. 2017 Dec 23;21(4):382–392. doi: 10.1093/ijnp/pyx118

Figure 2.

Figure 2.

Activation of ERβ is sufficient to enhance cocaine conditioned place preference (CPP) in ovariectomized (OVX) mice. (A) Timeline and design of the CPP experiment (5 mg/kg cocaine). (B) Graph of the time spent on the cocaine-paired side (in seconds) before conditioning (Test 1) and after conditioning (Test 2) of vehicle (VEH; n = 16), the ERα agonist (PPT; n = 11), and the ERβ agonist (DPN; n = 12)-treated mice. Significant main effect by 2-way RM ANOVA: ****P < .0001. #Indicates a significant difference between VEH - and DPN-treated mice on Test 2 (P < .01); Significant difference (**P < .01, ***P < .001, and ****P < .0001) between Test 1 and Test 2 within each treatment group by posthoc Holm-Sidak’s multiple comparisons test. (C) Preference scores (Test 2-Test 1, in seconds) of VEH-, PPT-, and DPN-treated mice. A 1-way ANOVA of preference scores demonstrated a significant difference between treatment groups (P < .05). Posthoc analysis revealed a significant increase in preference score in DPN- vs VEH-treated mice (*P < .05). Data are presented as the mean ± SEM.