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. 2018 Jan 31;46(6):2850–2867. doi: 10.1093/nar/gky049

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — TCF7L2 cooperates with cardiac-TFs to enable heart-specific gene regulation. (A) Comparison of TCF7L2-bound regions in in vivo models of β-catenin stabilization (β-cat^Δex3) in CMs and hepatocytes. GO biological processes for unique regions in CM (magenta) and hepatocytes (blue). (B) TCF7L2 occupancy profiles on identified Hand2, Tbx20, Rock2 and Dstn enhancers and common Wnt targets Axin2 and Lef1 in β-catenin stabilized CM (magenta) and hepatocytes (blue). (C) Table enlisting the transcription factors (TFs) enriched on TCF7L2-bound regions in β-cat^Δex3 ventricles by de-novo motif search using MEME-SpaMo. (D) Heatmap depicting the occupancy of cardiac-TFs GATA4 and NKX2.5 in the normal heart on regions occupied by TCF7L2 in β-cat^Δex3 hearts. Regions ± 5 kb are shown. (E) Average profiles of GATA4 and NKX2.5 occupancy on TCF7L2-bound liver and heart-specific regions. Data are mean ± SEM; t-test.