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. 2018 Feb 26;46(6):3009–3018. doi: 10.1093/nar/gky131

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Study the associations of SCNA (C), DNA methylation (M), and gene expression (E). (A) A gene-centric organization of the three types of data. Here, we focus on those cases with significant CM associations and the CpG is with 200 kb of the gene. (B) We compare the likelihood of three models and for each cancer type, and identify the number of CM pairs where one of the three models has significantly higher likelihood, or that the likelihoods of the top two models are not significantly different.