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. 2018 Feb 9;10(4):e7918. doi: 10.15252/emmm.201707918

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© 2018 The Authors. Published under the terms of the CC BY 4.0 license

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Figure EV1 — A
Collagen I induces DDR1 tyrosine phosphorylation (pY DDR1).

B, C
Nilotinib inhibits DDR1 tyrosine phosphorylation. DDR1 tyrosine phosphorylation level was assessed by Western blotting in protein lysates from the indicated CRC cell lines after stimulation with 40 μg/ml collagen I for 18 h and incubation with the indicated concentrations of nilotinib and for the indicated times with 100 nM of nilotinib.