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. 2018 Feb 9;10(4):e7918. doi: 10.15252/emmm.201707918

Figure EV2. RAS‐independent nature of DDR1 signalling.

Figure EV2

  • A, B
    Depletion of DDR1 abolishes (A) and overexpression of DDR1 induces (B) BCR but not MAPK or AKT phosphorylation. Tyrosine phosphorylation (pTyr) and phosphorylation levels of DDR1, BCR, MAPK and AKT were assessed by Western blotting in protein lysates from the indicated CRC cell lines stimulated or not with 40 μg/ml collagen I (Col I) for the indicated times.
  • C
    MAPK inhibition (treatment with 10 μM of PD98059 during 24 h) does not impact on DDR1 signalling.
  • D
    DDR1 signalling in CRC liver metastases. DDR1, BCR, MAPK and AKT activities from protein lysates of liver metastases described in Fig 3F.