Figure 8. Proposed model for kinase‐dependent DDR1 invasive activity in CRC cells.

1. Collagen‐stimulated DDR1 activation induces the phosphorylation of BCR on Tyr177, which disrupts BCR/β‐catenin interaction. This signalling cascade results in an increased β‐catenin nuclear activity leading to expression of target genes necessary for cell invasion.
2. Inhibition of DDR1 kinase activity with nilotinib decreases CRC cell invasion by reducing this β‐catenin‐dependent signalling cascade necessary for cell invasion.