Table 4.
Diagnostic accuracy outcomes without 2 × 2 table
| Study | Index Test | Cut‐off | Sensitivity, % | Specificity, % | AUC (95% CI) | PPV, % | NPV, % | LR+ | LR− |
|---|---|---|---|---|---|---|---|---|---|
| MCI | |||||||||
| Ahmed et al31 | CANS‐MCI | 0.5 | 89.0 | 73.0 | 0.867 (0.743‐0.990) | 60 | 84 | NR | NR |
| De Jager et al32 | CogState | ||||||||
| Accuracy | 82.6 | 78.0 | 90.0 | 0.86 (NR) | NR | NR | NR | NR | |
| Accuracy speed ratio | 3.54 | 76.0 | 79.0 | 0.84 (NR) | NR | NR | NR | NR | |
| Dwolatzky et al34 | Mindstreams computerised cognitive testing | NA for AUC | NR | NR | 0.84 (NR) | NR | NR | NR | NR |
| Kingsbury et al37 | CogniScreen | ||||||||
| Pair recognition | 0.47 | 76.0 | 60.0 | 0.72 (0.62‐0.83) | NR | NR | NR | NR | |
| Cued recall | 0.305 | 82.1 | 76.7 | 0.87 (0.80‐0.95) | NR | NR | NR | NR | |
| Immediate and delayed serial recall | 0.385 | 92.6 | 80.0 | 0.89 (0.81‐0.97) | NR | NR | NR | NR | |
| Kluger et al38 | Computerised test (no name) | NR | NR | NR | 0.89 | NR | NR | NR | NR |
| Maruff et al40 | CBB | ||||||||
| Psychomotor/attention | 90 | 41.1 | 85.7 | 0.67 (0.6‐0.73) | NR | NR | NR | NR | |
| Learning/working memory | 90 | 80.4 | 84.7 | 0.91 (0.87‐0.94) | NR | NR | NR | NR | |
| Tierney et al45 | CAMCI | 2 | 80.0 | 74.0 | NR | NR | NR | NR | NR |
| Vacante et al46 | Computerised total (novel and traditional) | 19.5 | 70.0 | 76.2 | NR | NR | NR | NR | NR |
| Computerised objects and faces (novel and traditional) | 12.5 | 50 | 64.3 | NR | NR | NR | NR | NR | |
| Computerised objects and faces (novel and traditional) | 13.5 | 75 | 52.4 | NR | NR | NR | NR | NR | |
| Early dementia | |||||||||
| Doniger et al33 | Mindstreams (abridged) | ||||||||
| Overall | NA | NR | NR | 0.886 | NR | NR | NR | NR | |
| Memory | |||||||||
| Verbal memory | NR | NR | 0.830 (0.762‐0.898) | NR | NR | NR | NR | ||
| Nonverbal memory | NR | NR | 0.825 (0.756‐0.893) | NR | NR | NR | NR | ||
| Executive function | |||||||||
| Go–No Go | NR | NR | 0.733 (0.640‐0.826) | NR | NR | NR | NR | ||
| Stoop interference | NR | NR | 0.790 (0.690‐0.890) | NR | NR | NR | NR | ||
| Catch game | NR | NR | 0.748 (0.670‐0.827) | NR | NR | NR | NR | ||
| Visual spatial | |||||||||
| Visual spatial imagery | NR | NR | 0.678 (0.567‐0.789) | NR | NR | NR | NR | ||
| Dwolatzky et al34 | Mindstreams computerized cognitive testing | NR | NR | NR | NR | NR | NR | NR | NR |
| Kluger et al38 | Computerised test (no name) | NR | NR | NR | 0.97 | NR | NR | NR | NR |
| Vacante et al46 | TPT | ||||||||
| Computerised total (novel and traditional) | 15.5 | 88.9 | 92.9 | NR | NR | NR | NR | NR | |
| Computerised objects and faces (novel and traditional) | 11.5 | 94.4 | 78.6 | NR | NR | NR | NR | NR | |
| Computerised objects and faces (novel and traditional) | 13.5 | 94.4 | 52.4 | NR | NR | NR | NR | NR | |
| MCI/early dementia | |||||||||
| Doniger et al33 | Mindstreams (abridged) | ||||||||
| Overall | NA for AUC | NR | NR | 0.823 (0.757‐0.888) | NR | NR | NR | NR | |
| Memory | |||||||||
| Verbal memory | 0.773(0.697‐0.849) | ||||||||
| Nonverbal memory | 0.767 (0.690‐0.844) | ||||||||
| Executive function | |||||||||
| Go–No Go | 0.719 (0.639‐0.800) | ||||||||
| Stoop interference | 0.671 (0.575‐0.766) | ||||||||
| Catch game | 0.685 (0.595‐0.776) | ||||||||
| Visual spatial | |||||||||
| Visual spatial imagery | 0.721 (0.638‐0.803) | ||||||||
| Lichtenberg et al39 | CST | 1.5 | 80.0 | 87.0 | NR | 88.0 | 79.0 | NR | NR |
Abbreviations: AUC, area under curve; CAMCI, Computer Assessment of Mild Cognitive Impairment; CANS‐MCI, Computer‐Administered Neuropsychological Screen for Mild Cognitive Impairment; CBB, CogState Brief Battery; CST, Computerised Self‐Test; LR−, negative likelihood ratio; LR+, positive likelihood ratio; MCI, mild cognitive impairment; NA, not applicable; NPV, negative predictive value; NR, not reported; PPV, positive predictive value; TPT, The Placing Test.