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. 2017 Sep 19;28(2):155–171. doi: 10.1111/bpa.12555

Figure 2.

Figure 2

Macroscopic and low power histological features of multinodular and vacuolating neuronal tumours (MVNT). A. Macroscopic features of the temporal lobe specimen from Case 1 show areas of breakdown/cavitation in the gyral cores and focal translucency of the white matter. B. Luxol fast blue/cresyl violet stained section from Case 1 confirms lack of myelin in some gyral cores (arrow) and pale hypomyelinated nodules at the cortical white matter junction extending into the white matter (arrowhead). C. SMI94/myelin basic protein confirms diffuse regions of poor myelination (arrow) and nodular like patterns (arrowhead) in the white matter in Case 1. D. Abnormal nodular islands of cells in the subiculum in Case 1, present on both sides of the pyramidal cell layer, although predominantly in the subcortical region (arrowhead). E. Macroscopic appearance of fixed 5 mm sections of the temporal lobe in Case 2 shows islands of grey tissue in the white matter of the inferior medial part of the specimen with an overlying normal‐appearing cortex. F. Synaptophysin labelling in Case 4 highlights the nodules encroaching on the deep cortical layers with reduced labelling compared to the adjacent cortex. G. Neuropeptide Y in Case 4 at low power shows reduction of labelling within the cortical nodules compared to adjacent cortex (arrowheads). H. MAP2 staining in Case 8 in the temporal cortex shows variable patterns with reduced MAP2 labelling in some nodules (arrowhead) compared to others (arrows). I. Myelin basic protein staining (SMI94) in Case 4 highlights abutting, myelin‐poor nodules. J. The abnormal white matter regions are populated by single scattered cells with a neuronal/ganglion cell appearance and prominent vacuolation of the cytoplasm or vacuoles surrounding the cells. K. Occasional binucleated cells were seen (arrowhead) and cells with more eosinophilic cytoplasm were observed in MVNT after H&E staining. L. In some cases alignment of the atypical cells along vessels was noted in the nodules (Case 4). M. The border (arrowhead) between a nodule in MVNT(top half of figure) and the white matter (lower half of figure) on cresyl violet stain gives the impression of overall reduced cellularity, particularly for small oligodendroglial‐like cells in the nodules, compared to the adjacent white matter. N. In Case 8, a focal area in the mesial temporal lobe showed more typical appearances of a ganglioglioma, with dysplastic neurones and eosinophilic granular bodies. Bar = 1cm for macroscopic images in A and E; = 3mm for B–D, F–H; =0.5mm for I; = 100 microns for J, L–N and =50 microns for K (approximate based on original magnifications).