Table 2.
Clinical details of cases in current series, location, salient MRI features and outcome following surgery. Case 1 was previously reported (Ratilal et al., 2007). PM = post mortem; AD = Alzheimer's disease; NA = not applicable; PS = partial seizures; GS = generalized seizures.
| Case | Presenting symptoms | Age onset of seizures (years) | Age at surgery (PM)/Gender | Type of seizures | Localization structures involved | Type of surgical resection | Any other relevant neurology | Outcome following surgery. Seizure control/tumour recurrence [period of follow up] |
|---|---|---|---|---|---|---|---|---|
| 1 | Seizures | 39 | 59/F | PS, GS | Left temporal lobe, parahippocampal gyrus, hippocampus and amygdala | Left temporal lobectomy, hippocampectomy and resection of amygdala | Declining verbal memory post operatively. Depression | Continued seizures (1–3 nocturnal seizure per week)/no recurrence of tumour [9 years] |
| 2 | Seizures/temporal lobe epilepsy | ‘epilepsy many years’ | 32/F | PS | Right temporal lobe, parahippocampal gyrus, hippocampus and amygdala | Right temporal lobectomy, hippocampectomy and resection of amygdala | Impaired non‐verbal learning. Migraine | Seizure‐free/no recurrence [6 years] |
| 3 | Seizures | 10 | 27/F | PS, GS | Left amygdala and hippocampus | Left temporal lobectomy, hippocampectomy and resection of amygdala | Psychosis following temporal lobectomy | Seizure‐free/no recurrence on MRI [14 years] |
| 4 | Breathing difficulties | NA | 62/M | No history of epilepsy | Right occipital lobe | Post mortem: whole brain | Braak stage V AD diagnosed at PM Cause of death mesothelioma | NA |
| 5 | Visual symptoms/seizures | 65 | 67/F | PS | Right posterior parietal‐temporal lobe lesion | Lesionectomy | None | No neurological deficit and seizure free/lesion stable [2 years] |
| 6 | Seizures/speech arrest | 47 | 48/F | PS, GS | Left middle temporal gyrus | Lesionectomy/awake craniotomy | None | Seizure‐free/residual tumour but no progression on MRI [2 years] |
| 7 | Seizures | 6/M | Left temporal | Left temporal neocortex, hippocampectomy | Seizure‐free/residual tumour on MRI but no progression [17 months] | |||
| 8 | Seizures | 21 | 54/M | PS,GS | Right temporal lobe, parahippocampal gyrus, fusiform gyrus and hippocampus | Temporal lobe, hippocampectomy | Postictal psychosis/post operative facial weakness | Seizure‐free/no progression [10 months] |
| 9 | Epilepsy | 41/F | Right mesial temporal lesion | Temporal lobe resection | Partial resection but no progression on MRI | |||
| 10 | Epilepsy | 55/M | CPS | Temporal lobe and temporal pole | Temporal lobe resection | Recent surgery, Limited follow up data |