Table 3.
AUROC, sensitivity and specificity for each biomarker
| Biomarker | AUC 95% CI | Sensitivity at predefined threshold 95% CI | Specificity at predefined threshold 95% CI | Sensitivity at threshold with optimal sensitivity 95% CI | Specificity at threshold with optimal sensitivity 95% CI |
|---|---|---|---|---|---|
| APTT |
0·669 0·570 to 0·768 |
0·088 0·019 to 0·237 |
0·914 0·870 to 0·947 |
0·971 0·847 to 0·999 |
0·086 0·053 to 0·130 |
| BNP |
0·549 0·453 to 0·645 |
0·167 0·064 to 0·328 |
0·879 0·831 to 0·917 |
0·972 0·855 to 0·999 |
0·146 0·104 to 0·196 |
| C‐Reactive protein |
0·542 0·445 to 0·639 |
0·861 0·705 to 0·953 |
0·121 0·083 to 0·169 |
0·972 0·855 to 0·999 |
0·032 0·014 to 0·063 |
| Clauss fibrinogen |
0·589 0·476 to 0·701 |
0·778 0·608 to 0·899 |
0·228 0·177 to 0·286 |
0·972 0·855 to 0·999 |
0·066 0·038 to 0·106 |
| D‐Dimer (ELISA) |
0·668 0·561 to 0·776 |
0·861 0·705 to 0·953 |
0·196 0·148 to 0·251 |
0·972 0·855 to 0·999 |
0·037 0·017 to 0·069 |
| D‐Dimer (Innovance) |
0·651 0·545 to 0·758 |
0·528 0·355 to 0·696 |
0·727 0·666 to 0·781 |
0·972 0·855 to 0·999 |
0·078 0·047 to 0·118 |
| MRproANP |
0·524 0·418 to 0·630 |
0·278 0·142 to 0·452 |
0·785 0·729 to 0·835 |
0·972 0·855 to 0·999 |
0·097 0·063 to 0·141 |
| Prothrombin fragment 1 + 2 |
0·562 0·462 to 0·661 |
0·056 0·007 to 0·187 |
0·935 0·896 to 0·962 |
0·972 0·855 to 0·999 |
0·045 0·023 to 0·079 |
| Plasmin‐antiplasmin complexes |
0·639 0·536 to 0·742 |
0·472 0·304 to 0·645 |
0·763 0·705 to 0·815 |
0·972 0·855 to 0·999 |
0·041 0·020 to 0·074 |
| Prothombin Time |
0·613 0·508 to 0·718 |
0·486 0·314 to 0·660 |
0·730 0·669 to 0·785 |
0·971 0·851 to 0·999 |
0·084 0·052 to 0·127 |
| Thrombin Generation (Lag Time) |
0·702 0·598 to 0·806 |
1·000 0·888 to 1·000 |
0·000 0·000 to 0·017 |
0·968 0·833 to 0·999 |
0·251 0·195 to 0·314 |
| Thrombin Generation (Endogenous Potential) |
0·559 0·437 to 0·681 |
0·167 0·064 to 0·328 |
0·755 0·696 to 0·808 |
0·962 0·804 to 0·999 |
0·069 0·038 to 0·112 |
| Thrombin Generation (Peak) |
0·596 0·478 to 0·715 |
0·000 0·000 to 0·097 |
0·996 0·977 to 1·000 |
0·968 0·833 to 0·999 |
0·059 0·032 to 0·099 |
| Thrombin Generation (Time to Peak) |
0·655 0·541 to 0·769 |
0·861 0·705 to 0·953 |
0·204 0·155 to 0·260 |
1·000 0·888 to 1·000 |
0·114 0·075 to 0·164 |
| Soluble Tissue Factor |
0·531 0·424 to 0·638 |
0·222 0·101 to 0·392 |
0·771 0·714 to 0·822 |
0·972 0·855 to 0·999 |
0·037 0·017 to 0·069 |
| Troponin |
0·597 0·499 to 0·695 |
0·056 0·007 to 0·187 |
0·887 0·840 to 0·923 |
0·972 0·855 to 0·999 |
0·085 0·053 to 0·127 |
95% CI, 95% confidence interval; APTT, activated partial thromboplastin time; AUC, area under the curve; AUROC, area under the receiver operator characteristic curve; BNP, brain natriuretic peptide; ELISA, enzyme‐linked immunosorbent assay; MRproANP, mid‐regional pro‐atrial natriuretic peptide.